Seizure Suppression by High Temperature via cAMP Modulation in Drosophila

Seizure Suppression by High Temperature via cAMP Modulation in Drosophila

Bang-sensitive (BS) Drosophila mutants display characteristic seizure-like activity (SLA) and paralysis after mechanical shock . After high-frequency electrical stimulation (HFS) of the brain, they generate robust seizures at very low threshold voltage. Here we report an important phenomenon, which effectively suppresses SLA in BS mutants. High temperature causes seizure suppression in all BS m...

Neurobiology of Disease Seizure Suppression by top1 Mutations in Drosophila

DNA topoisomerase I is an essential nuclear enzyme involved in resolving the torsional stress associated with DNA replication, transcription, and chromatin condensation. Here we report the discovery of a seizure-suppressor mutant, top1, which suppresses seizures in a Drosophila model of human epilepsy. A P-element mutagenesis screen using easily shocked seizure-sensitive mutant as a genetic bac...

Characterization of Seizure Suppression in Drosophila by Iris Christine Howlett

Seizure Suppression by shakB, a Gap Junction Mutation in Drosophila

Song, Juan and Mark A. Tanouye. Seizure suppression by shakB, a gap junction mutation in Drosophila. J Neurophysiol 95: 627–635, 2006. First published September 28, 2005; doi:10.1152/jn.01059.2004. Gap junction proteins mediate electrical synaptic transmission. In Drosophila, flies carrying null mutations in the shakB locus, such as shakB, have behavioral and electrophysiological defects in the...

Seizure suppression by shakB2, a gap junction mutation in Drosophila.

Gap junction proteins mediate electrical synaptic transmission. In Drosophila, flies carrying null mutations in the shakB locus, such as shakB2, have behavioral and electrophysiological defects in the giant fiber (GF) system neurocircuit consistent with a loss of transmission at electrical synapses. The shakB2 mutation also affects seizure susceptibility. Mutant flies are especially seizure-res...